The expression of NGAL in the kidney will be significantly increased due to different causes of renal injury, and it will be released into urine and plasma.
Under normal circumstances, NGAL maintains a low level in urine and plasma, but rises rapidly in a very short period of time (starting to rise 2 hours after the onset of AKI) in cases of kidney injury.
As an excellent marker for early diagnosis of AKI, NGAL can be used for risk stratification of AKI, treatment monitoring and prognosis assessment.
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