Hepatitis B virus is a hepatotropic DNA virus that mainly transmits through blood. According to World Health Organization (WHO), there are approximately 296 million chronic hepatitis B (CHB) patients worldwide, and about 820,000 deaths from HBV infection-related diseases every year.
Currently, antiviral drugs (nucleoside (acid) analogs [NAs] and pegylated interferon ( PEG-lFN-α)) cannot eradicate covalently closed circular DNA (cccDNA) in the liver. cccDNA in the nucleus can transcribe pregenomic RNA (pgRNA), and subsequently, HBV. HBV RNA in serum is pgRNA, whose level relects the transcriptional activity of cccDNA.
Panel | Parameter | Registration certificate | Sample type |
CHB | HBV-RNA | NMPA | Serum |
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